Tim Tolker-Nielsen Selected Research

bis(3',5')-cyclic diguanylic acid

5/2024	High efficacy treatment of murine Pseudomonas aeruginosa catheter-associated urinary tract infections using the c-di-GMP modulating anti-biofilm compound Disperazol in combination with ciprofloxacin.
1/2022	Elevated c-di-GMP Levels and Expression of the Type III Secretion System Promote Corneal Infection by Pseudomonas aeruginosa.
1/2021	Identification of small molecules that interfere with c-di-GMP signaling and induce dispersal of Pseudomonas aeruginosa biofilms.
1/2021	Carbon starvation of Pseudomonas aeruginosa biofilms selects for dispersal insensitive mutants.
7/2015	The Cyclic AMP-Vfr Signaling Pathway in Pseudomonas aeruginosa Is Inhibited by Cyclic Di-GMP.
8/2013	Clearance of Pseudomonas aeruginosa foreign-body biofilm infections through reduction of the cyclic Di-GMP level in the bacteria.
8/2012	Fluorescence-based reporter for gauging cyclic di-GMP levels in Pseudomonas aeruginosa.

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Tim Tolker-Nielsen Research Topics

Disease

25	Infections 05/2024 - 10/2009
9	Persistent Infection 05/2024 - 01/2011
6	Cystic Fibrosis (Mucoviscidosis) 02/2023 - 08/2009
4	Starvation 01/2021 - 06/2005
3	Urinary Tract Infections (Urinary Tract Infection) 05/2024 - 08/2015
3	Wounds and Injuries (Trauma) 01/2019 - 08/2008
3	Bacterial Infections (Bacterial Infection) 10/2016 - 09/2007
2	ST Elevation Myocardial Infarction 01/2016 - 01/2015
2	Leg Ulcer 05/2011 - 12/2009
1	Pseudomonas Infections 01/2023
1	Cardiac Arrhythmias (Arrythmia) 01/2022
1	Chronic Obstructive Pulmonary Disease (COPD) 01/2019
1	Endocarditis 01/2019
1	Sepsis (Septicemia) 01/2019
1	Ventilator-Associated Pneumonia 01/2019
1	Parkinson Disease (Parkinson's Disease) 01/2018
1	Stroke (Strokes) 09/2015
1	Transient Ischemic Attack 09/2015
1	Atherosclerotic Plaque (Atheroma) 09/2015
1	Stable Angina 01/2015
1	Unstable Angina 01/2015
1	Non-ST Elevated Myocardial Infarction 01/2015
1	Pneumonia (Pneumonitis) 11/2014
1	Foreign Bodies (Foreign Body) 08/2013
1	Bronchopneumonia 08/2012
1	Inflammation (Inflammations) 04/2011

Drug/Important Bio-Agent (IBA)

21	Anti-Bacterial Agents (Antibiotics)IBA 05/2024 - 01/2011
7	bis(3',5')-cyclic diguanylic acidIBA 05/2024 - 08/2012
3	CarbonIBA 01/2021 - 06/2005
3	Peptide Nucleic AcidsIBA 05/2011 - 08/2008
2	Type III Secretion SystemsIBA 01/2022 - 11/2014
2	Proteins (Proteins, Gene)FDA Link 01/2018 - 06/2005
2	DNA (Deoxyribonucleic Acid)IBA 05/2013 - 08/2009
1	Ciprofloxacin (Cipro)FDA LinkGeneric 05/2024
1	Rifampin (Rifampicin)FDA LinkGeneric 01/2023
1	Colistin (Coly-Mycin)FDA Link 01/2023
1	5'-palmitoyl cytarabine (PLAC)IBA 01/2022
1	Topoisomerase InhibitorsIBA 01/2022
1	4-nitrobenzylthioinosineIBA 01/2022
1	DNA Topoisomerase IV (Topoisomerase IV)IBA 01/2022
1	DNA GyraseIBA 01/2022
1	AlginatesIBA 01/2022
1	HydrogelsIBA 01/2022
1	Potassium Channels (Potassium Channel)IBA 01/2022
1	EnzymesIBA 01/2022
1	Green Fluorescent ProteinsIBA 01/2021
1	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 01/2021
1	Polysaccharides (Glycans)IBA 03/2020
1	cyclic diadenosine phosphateIBA 01/2019
1	Surface-Active Agents (Surfactants)IBA 01/2018
1	SynucleinsIBA 01/2018
1	Bacterial DNAIBA 01/2016
1	OligosaccharidesIBA 08/2015
1	Virulence Factors (Pathogenicity Factors)IBA 07/2015
1	16S Ribosomal RNAIBA 01/2015
1	Lipase (Acid Lipase)FDA Link 01/2014
1	AnhydridesIBA 01/2014
1	EstersIBA 01/2014
1	Fatty Acids (Saturated Fatty Acids)IBA 01/2014
1	IronIBA 01/2011
1	AgarIBA 09/2010
1	N-butyrylhomoserine lactoneIBA 04/2010
1	N-(3-oxododecanoyl)homoserine lactoneIBA 04/2010
1	polyacrylamideIBA 10/2009
1	Actins (F Actin)IBA 08/2009
1	Nucleic AcidsIBA 09/2007
1	Benzoates (Benzoate)IBA 07/2007
1	Oxygen (Dioxygen)IBA 07/2007

Therapy/Procedure

3	Lasers (Laser) 11/2011 - 12/2009
2	Catheters 05/2024 - 01/2019
2	Therapeutics 01/2021 - 08/2009
1	Phage Therapy 01/2019
1	Percutaneous Coronary Intervention 01/2016
1	Endarterectomy (Thromboendarterectomy) 09/2015
1	Peritoneal Dialysis 04/2013